SuicidDentistV1, Main, Exploration, bibRecord, 000060

Optical pH measurement system using a single fluorescent dye for assessing susceptibility to dental caries.

Identifieur interne : 000060 ( Main/Exploration ); précédent : 000059; suivant : 000061

Optical pH measurement system using a single fluorescent dye for assessing susceptibility to dental caries.

Auteurs : Manuja Sharma [États-Unis] ; Jasmine Y. Graham [États-Unis] ; Philip A. Walczak [États-Unis] ; Ryan Nguyen [États-Unis] ; Lauren K. Lee [États-Unis] ; Matthew D. Carson [États-Unis] ; Leonard Y. Nelson [États-Unis] ; Shwetak N. Patel [États-Unis] ; Zheng Xu [États-Unis] ; Eric J. Seibel [États-Unis]

Source :

Journal of biomedical optics [ 1560-2281 ] ; 2019.

RBID : pubmed:30623630

Descripteurs français

KwdFr :
- Adulte (MeSH), Algorithmes (MeSH), Biofilms (MeSH), Calibrage (MeSH), Caries dentaires (imagerie diagnostique), Colorants fluorescents (composition chimique), Concentration en ions d'hydrogène (MeSH), Déminéralisation dentaire (MeSH), Femelle (MeSH), Humains (MeSH), Hygiène buccodentaire (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Optique et photonique (MeSH), Plaque dentaire (imagerie diagnostique), Projets pilotes (MeSH), Saccharose (composition chimique), Spectrométrie de fluorescence (instrumentation), Spectrométrie de fluorescence (méthodes), Substances tampon (MeSH), Émail dentaire (imagerie diagnostique).
MESH :
- composition chimique : Colorants fluorescents, Saccharose.
- imagerie diagnostique : Caries dentaires, Plaque dentaire, Émail dentaire.
- méthodes : Spectrométrie de fluorescence.
- Adulte, Algorithmes, Biofilms, Calibrage, Concentration en ions d'hydrogène, Déminéralisation dentaire, Femelle, Humains, Hygiène buccodentaire, Jeune adulte, Mâle, Optique et photonique, Projets pilotes, Spectrométrie de fluorescence, Substances tampon.

English descriptors

KwdEn :
- Adult (MeSH), Algorithms (MeSH), Biofilms (MeSH), Buffers (MeSH), Calibration (MeSH), Dental Caries (diagnostic imaging), Dental Enamel (diagnostic imaging), Dental Plaque (diagnostic imaging), Female (MeSH), Fluorescent Dyes (chemistry), Humans (MeSH), Hydrogen-Ion Concentration (MeSH), Male (MeSH), Optics and Photonics (MeSH), Oral Hygiene (MeSH), Pilot Projects (MeSH), Spectrometry, Fluorescence (instrumentation), Spectrometry, Fluorescence (methods), Sucrose (chemistry), Tooth Demineralization (MeSH), Young Adult (MeSH).
MESH :
- chemical , chemistry : Fluorescent Dyes, Sucrose.
- chemical : Buffers.
- diagnostic imaging : Dental Caries, Dental Enamel, Dental Plaque.
- instrumentation : Spectrometry, Fluorescence.
- methods : Spectrometry, Fluorescence.
- Adult, Algorithms, Biofilms, Calibration, Female, Humans, Hydrogen-Ion Concentration, Male, Optics and Photonics, Oral Hygiene, Pilot Projects, Tooth Demineralization, Young Adult.

Abstract

Sugar-rich diets and poor dental hygiene promote the formation of a biofilm (plaque) that strongly adheres to the dental enamel surface and fosters the evolution of aciduric bacteria. The acid contributes to demineralization of the exterior tooth enamel, which accelerates after the pH drops below a critical value (∼5.5) for extended time periods resulting in the need for restorative procedures. Preventative techniques to alert the dentist and caries-susceptible patients regarding vulnerability to dental decay require a clinical measure of plaque activity. Therefore, there is a need to evaluate the acid production capability of plaque deposits in the pits and fissures of occlusal and interproximal regions. A ratiometric fluorescence pH-sensing device has been developed using an FDA-approved dye and LED excitation. Fluorescein spectral profiles were collected using a spectrometer and analyzed with a spectral unmixing algorithm for calibration over the pH range of 4.5 to 7. An in vivo pilot study on human subjects was performed using a sucrose rinse to accelerate bacterial metabolism and to measure the time-dependent drop in pH. The optical system is relatively immune to confounding factors such as photobleaching, dye concentration, and variation in excitation intensity associated with earlier dye-based pH measurement techniques.

DOI: 10.1117/1.JBO.24.1.017001
PubMed: 30623630
PubMed Central: PMC6985695

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Algorithms (MeSH)</term>
<term>Biofilms (MeSH)</term>
<term>Buffers (MeSH)</term>
<term>Calibration (MeSH)</term>
<term>Dental Caries (diagnostic imaging)</term>
<term>Dental Enamel (diagnostic imaging)</term>
<term>Dental Plaque (diagnostic imaging)</term>
<term>Female (MeSH)</term>
<term>Fluorescent Dyes (chemistry)</term>
<term>Humans (MeSH)</term>
<term>Hydrogen-Ion Concentration (MeSH)</term>
<term>Male (MeSH)</term>
<term>Optics and Photonics (MeSH)</term>
<term>Oral Hygiene (MeSH)</term>
<term>Pilot Projects (MeSH)</term>
<term>Spectrometry, Fluorescence (instrumentation)</term>
<term>Spectrometry, Fluorescence (methods)</term>
<term>Sucrose (chemistry)</term>
<term>Tooth Demineralization (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Algorithmes (MeSH)</term>
<term>Biofilms (MeSH)</term>
<term>Calibrage (MeSH)</term>
<term>Caries dentaires (imagerie diagnostique)</term>
<term>Colorants fluorescents (composition chimique)</term>
<term>Concentration en ions d'hydrogène (MeSH)</term>
<term>Déminéralisation dentaire (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hygiène buccodentaire (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Optique et photonique (MeSH)</term>
<term>Plaque dentaire (imagerie diagnostique)</term>
<term>Projets pilotes (MeSH)</term>
<term>Saccharose (composition chimique)</term>
<term>Spectrométrie de fluorescence (instrumentation)</term>
<term>Spectrométrie de fluorescence (méthodes)</term>
<term>Substances tampon (MeSH)</term>
<term>Émail dentaire (imagerie diagnostique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fluorescent Dyes</term>
<term>Sucrose</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Buffers</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Colorants fluorescents</term>
<term>Saccharose</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Dental Caries</term>
<term>Dental Enamel</term>
<term>Dental Plaque</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Caries dentaires</term>
<term>Plaque dentaire</term>
<term>Émail dentaire</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Spectrometry, Fluorescence</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Spectrometry, Fluorescence</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Spectrométrie de fluorescence</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Algorithms</term>
<term>Biofilms</term>
<term>Calibration</term>
<term>Female</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Male</term>
<term>Optics and Photonics</term>
<term>Oral Hygiene</term>
<term>Pilot Projects</term>
<term>Tooth Demineralization</term>
<term>Young Adult</term>
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<term>Algorithmes</term>
<term>Biofilms</term>
<term>Calibrage</term>
<term>Concentration en ions d'hydrogène</term>
<term>Déminéralisation dentaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hygiène buccodentaire</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Optique et photonique</term>
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<front><div type="abstract" xml:lang="en">Sugar-rich diets and poor dental hygiene promote the formation of a biofilm (plaque) that strongly adheres to the dental enamel surface and fosters the evolution of aciduric bacteria. The acid contributes to demineralization of the exterior tooth enamel, which accelerates after the pH drops below a critical value (∼5.5) for extended time periods resulting in the need for restorative procedures. Preventative techniques to alert the dentist and caries-susceptible patients regarding vulnerability to dental decay require a clinical measure of plaque activity. Therefore, there is a need to evaluate the acid production capability of plaque deposits in the pits and fissures of occlusal and interproximal regions. A ratiometric fluorescence pH-sensing device has been developed using an FDA-approved dye and LED excitation. Fluorescein spectral profiles were collected using a spectrometer and analyzed with a spectral unmixing algorithm for calibration over the pH range of 4.5 to 7. An in vivo pilot study on human subjects was performed using a sucrose rinse to accelerate bacterial metabolism and to measure the time-dependent drop in pH. The optical system is relatively immune to confounding factors such as photobleaching, dye concentration, and variation in excitation intensity associated with earlier dye-based pH measurement techniques.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30623630</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>04</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1560-2281</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>24</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
<Month>01</Month>
</PubDate>
</JournalIssue>
<Title>Journal of biomedical optics</Title>
<ISOAbbreviation>J Biomed Opt</ISOAbbreviation>
</Journal>
<ArticleTitle>Optical pH measurement system using a single fluorescent dye for assessing susceptibility to dental caries.</ArticleTitle>
<Pagination><MedlinePgn>1-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1117/1.JBO.24.1.017001</ELocationID>
<Abstract><AbstractText>Sugar-rich diets and poor dental hygiene promote the formation of a biofilm (plaque) that strongly adheres to the dental enamel surface and fosters the evolution of aciduric bacteria. The acid contributes to demineralization of the exterior tooth enamel, which accelerates after the pH drops below a critical value (∼5.5) for extended time periods resulting in the need for restorative procedures. Preventative techniques to alert the dentist and caries-susceptible patients regarding vulnerability to dental decay require a clinical measure of plaque activity. Therefore, there is a need to evaluate the acid production capability of plaque deposits in the pits and fissures of occlusal and interproximal regions. A ratiometric fluorescence pH-sensing device has been developed using an FDA-approved dye and LED excitation. Fluorescein spectral profiles were collected using a spectrometer and analyzed with a spectral unmixing algorithm for calibration over the pH range of 4.5 to 7. An in vivo pilot study on human subjects was performed using a sucrose rinse to accelerate bacterial metabolism and to measure the time-dependent drop in pH. The optical system is relatively immune to confounding factors such as photobleaching, dye concentration, and variation in excitation intensity associated with earlier dye-based pH measurement techniques.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sharma</LastName>
<ForeName>Manuja</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>University of Washington, Electrical and Computer Engineering, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Graham</LastName>
<ForeName>Jasmine Y</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>University of California, Berkeley - University of California, San Francisco, Department of Bioengin, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Walczak</LastName>
<ForeName>Philip A</ForeName>
<Initials>PA</Initials>
<AffiliationInfo><Affiliation>University of Washington, School of Dentistry, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nguyen</LastName>
<ForeName>Ryan</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>University of Washington, Department of Microbiology, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Lauren K</ForeName>
<Initials>LK</Initials>
<AffiliationInfo><Affiliation>University of Washington, Department of Biochemistry, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carson</LastName>
<ForeName>Matthew D</ForeName>
<Initials>MD</Initials>
<AffiliationInfo><Affiliation>University of Washington, Human Photonics Lab, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Washington, Department of Mechanical Engineering, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nelson</LastName>
<ForeName>Leonard Y</ForeName>
<Initials>LY</Initials>
<AffiliationInfo><Affiliation>University of Washington, Human Photonics Lab, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Washington, Department of Mechanical Engineering, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Patel</LastName>
<ForeName>Shwetak N</ForeName>
<Initials>SN</Initials>
<AffiliationInfo><Affiliation>University of Washington, Electrical and Computer Engineering, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Zheng</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>University of Washington, School of Dentistry, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seibel</LastName>
<ForeName>Eric J</ForeName>
<Initials>EJ</Initials>
<AffiliationInfo><Affiliation>University of Washington, Electrical and Computer Engineering, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Washington, Human Photonics Lab, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Washington, Department of Mechanical Engineering, Seattle, Washington, United States.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Biomed Opt</MedlineTA>
<NlmUniqueID>9605853</NlmUniqueID>
<ISSNLinking>1083-3668</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002021">Buffers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005456">Fluorescent Dyes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>57-50-1</RegistryNumber>
<NameOfSubstance UI="D013395">Sucrose</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>J Biomed Opt. 2021 Jan;26(1):</RefSource>
<PMID Version="1">33442964</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000465" MajorTopicYN="N">Algorithms</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018441" MajorTopicYN="N">Biofilms</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002021" MajorTopicYN="N">Buffers</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002138" MajorTopicYN="N">Calibration</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003731" MajorTopicYN="N">Dental Caries</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003743" MajorTopicYN="N">Dental Enamel</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003773" MajorTopicYN="N">Dental Plaque</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005456" MajorTopicYN="N">Fluorescent Dyes</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006863" MajorTopicYN="N">Hydrogen-Ion Concentration</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055095" MajorTopicYN="N">Optics and Photonics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009910" MajorTopicYN="N">Oral Hygiene</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013050" MajorTopicYN="N">Spectrometry, Fluorescence</DescriptorName>
<QualifierName UI="Q000295" MajorTopicYN="Y">instrumentation</QualifierName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013395" MajorTopicYN="N">Sucrose</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017001" MajorTopicYN="N">Tooth Demineralization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">anion</Keyword>
<Keyword MajorTopicYN="Y">caries</Keyword>
<Keyword MajorTopicYN="Y">dianion</Keyword>
<Keyword MajorTopicYN="Y">fluorescein</Keyword>
<Keyword MajorTopicYN="Y">fluorescence</Keyword>
<Keyword MajorTopicYN="Y">pH</Keyword>
<Keyword MajorTopicYN="Y">plaque</Keyword>
<Keyword MajorTopicYN="Y">unmixing</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>10</Month>
<Day>05</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>12</Month>
<Day>07</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>4</Month>
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<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Washington (État)</li>
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<tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Sharma, Manuja" sort="Sharma, Manuja" uniqKey="Sharma M" first="Manuja" last="Sharma">Manuja Sharma</name>
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<name sortKey="Carson, Matthew D" sort="Carson, Matthew D" uniqKey="Carson M" first="Matthew D" last="Carson">Matthew D. Carson</name>
<name sortKey="Carson, Matthew D" sort="Carson, Matthew D" uniqKey="Carson M" first="Matthew D" last="Carson">Matthew D. Carson</name>
<name sortKey="Graham, Jasmine Y" sort="Graham, Jasmine Y" uniqKey="Graham J" first="Jasmine Y" last="Graham">Jasmine Y. Graham</name>
<name sortKey="Lee, Lauren K" sort="Lee, Lauren K" uniqKey="Lee L" first="Lauren K" last="Lee">Lauren K. Lee</name>
<name sortKey="Nelson, Leonard Y" sort="Nelson, Leonard Y" uniqKey="Nelson L" first="Leonard Y" last="Nelson">Leonard Y. Nelson</name>
<name sortKey="Nelson, Leonard Y" sort="Nelson, Leonard Y" uniqKey="Nelson L" first="Leonard Y" last="Nelson">Leonard Y. Nelson</name>
<name sortKey="Nguyen, Ryan" sort="Nguyen, Ryan" uniqKey="Nguyen R" first="Ryan" last="Nguyen">Ryan Nguyen</name>
<name sortKey="Patel, Shwetak N" sort="Patel, Shwetak N" uniqKey="Patel S" first="Shwetak N" last="Patel">Shwetak N. Patel</name>
<name sortKey="Seibel, Eric J" sort="Seibel, Eric J" uniqKey="Seibel E" first="Eric J" last="Seibel">Eric J. Seibel</name>
<name sortKey="Seibel, Eric J" sort="Seibel, Eric J" uniqKey="Seibel E" first="Eric J" last="Seibel">Eric J. Seibel</name>
<name sortKey="Seibel, Eric J" sort="Seibel, Eric J" uniqKey="Seibel E" first="Eric J" last="Seibel">Eric J. Seibel</name>
<name sortKey="Walczak, Philip A" sort="Walczak, Philip A" uniqKey="Walczak P" first="Philip A" last="Walczak">Philip A. Walczak</name>
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	Serveur d'exploration sur le suicide chez les dentistes
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Serveur d'exploration sur le suicide chez les dentistes

Optical pH measurement system using a single fluorescent dye for assessing susceptibility to dental caries.

Optical pH measurement system using a single fluorescent dye for assessing susceptibility to dental caries.

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